MacBeth evidence of despair

Macbeth "...our fears in Banquo stick deep . . .There is none but he whose being I do fear" (III, 1).
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Murder "Fleance (Banquo's son) is 'caped."
Macbeth "Then comes my fit again: . . .I am bound in to saucy doubts and fears" (III, iv)

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MacBeth
to Banquo's ghost:
"Avaunt! and quit my sight! let the earth hide thee!/Thy bones are marrowless, thy blood is cold;/Thou hast no speculation in those eyes/Which thou dost glare with" (III, iv)

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IV, i  the second witches scene

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Lady Macbeth
"Out, damned spot, I say!" ( V, i)

"To bed, to bed; there's knocking at the gate:  come, come, come, give me your hand: what's done cannot be undone: to bed, to bed, to bed." (V, i)

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Seyton
"The queen, my lord, is dead."

Macbeth
"She should have died hereafter . . .Life's but a walking shadow,  . . .signifying nothing" (V, v)